2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N3414
    Kushenol L 101236-50-4 98%
    Kushenol L is one of the main components of EtOA cextracts from Kushen, a traditional medicinal herb derived from the dried roots of Sophora flavescens Ait. Kushenol L is a flavonoid and plays an important role in anti-diabeticeffects.
    Kushenol L
  • HY-N3426
    Kazinol B 99624-27-8 98%
    Kazinol B, a prenylated flavan with a dimethyl pyrane ring, is an inhibitor of nitric oxide (NO) production. Kazinol B improves insulin sensitivity by enhancing glucose uptake via the insulin-Akt signaling pathway and AMPK activation. Kazinol B has the potential for diabetes mellitus research.
    Kazinol B
  • HY-N4069
    Lupinalbin A 98094-87-2 98%
    Lupinalbin A (Boeravinone L) is a dipeptidyl peptidase 4 (DPP4) and α-glucosidase inhibitor with IC50 values ​​of 45.2 and 53.4 µM, respectively. Lupinalbin A exhibits antidiabetic activity.
    Lupinalbin A
  • HY-N6921
    11-​Oxomogroside III 952481-53-7 98%
    11-Oxomogroside III is a cucurbitane triterpene glycoside isolated from in Siraitia grosvenorii fruits.
    11-​Oxomogroside III
  • HY-N7165
    3-O-cis-p-Coumaroyl maslinic acid 69297-40-1 98%
    3-O-cis-p-Coumaroyl maslinic acid (compound 16) is a natural compound isolated from the ethyl acetate extract of leaves of Miconia albicans.3-O-cis-p-Coumaroyl maslinic acid can inhibit PTP1B, with the IC50 of 0.46 μM, and shows antimicrobial activity on Gram-positive bacteria and yeasts.
    3-O-cis-p-Coumaroyl maslinic acid
  • HY-N7736
    Furan fatty acid F5 57818-37-8 98%
    12,15-epoxy-13-methyl-12,14-Eicosadienoic acid is a furan fatty acid originally isolated from northern pike (E. lucius).1 Levels of 12,15-epoxy-13-methyl-12,14-eicosadienoic acid are increased in the liver of starving cod.
    Furan fatty acid F5
  • HY-N7835
    Methyl dotriacontanoate 41755-79-7 98%
    Dotriacontanoic acid methyl ester is a naturally occurring fatty acid methyl ester that has been found in the cuticular wax of P. abies needles. It has also been found in sediment samples from the Harney River in Florida and Lake Kivu in the East African rift valley.
    Methyl dotriacontanoate
  • HY-N7865
    1,2-Palmitolein-3-olein 107196-42-9 98%
    1,2-Palmitolein-3-olein (1,2-Dipalmitoleoyl-3-Oleoyl-rac-glycerol) is a triacylglycerol found in the fat body of bumblebees.
    1,2-Palmitolein-3-olein
  • HY-N7953
    1,2-Dioleoyl-3-linoleoyl-rac-glycerol 2190-20-7 98%
    1,2-Dioleoyl-3-linoleoyl-rac-glycerol (OOL) is a triacylglycerol containing oleic acid at the sn-1 and sn-2 positions and linoleic acid at the sn-3 position. It is found in a variety of seed and vegetable oils, including pumpkin seed, olive, and sesame oils.
    1,2-Dioleoyl-3-linoleoyl-rac-glycerol
  • HY-N7960
    (2S)-Pteroside A 35910-15-7 98%
    (2S)-Pteroside A is a pteroside from the rhizomes of subsp. aquilinum of bracken fern, which is promising for research of diabetic diseases.
    (2S)-Pteroside A
  • HY-N8134
    2-Methoxy-5-acetoxy-fruranogermacr-1(10)-en-6-one 1809980-25-3 98%
    2-Methoxy-5-acetoxy-fruranogermacr-1(10)-en-6-one is a natural product found in the leaves and stem bark of M. glabra. 2-Methoxy-5-acetoxy-fruranogermacr-1(10)-en-6-one displays binding affinities with dipeptidyl peptidase-4 (DPP-4) and α-Amylase. 2-Methoxy-5-acetoxy-fruranogermacr-1(10)-en-6-one has potential antidiabetic activities.
    2-Methoxy-5-acetoxy-fruranogermacr-1(10)-en-6-one
  • HY-N8279
    β-1,3-1,4-Glucanase 62213-14-3 98%
    β-1,3-1,4-Glucanase catalyzes the hydrolysis ofβ-glucan into low molecular weight glucose polymers, thus reducing the hydrophilicity and viscosity of chyme and eliminating the anti-nutritional negative effect. β-1,3-1,4-glucanase can improve feed intake, enhance animal production, regulate cecal microbiota and increase feed conversion ratio.
    β-1,3-1,4-Glucanase
  • HY-N8325
    Phomosine D 874918-37-3 98%
    Phomosine D is a fungal metabolite originally isolated from Phomopsis.
    Phomosine D
  • HY-N8341
    Alphitonin 493-36-7 98%
    Alphitonin is a flavonoid and is also a metabolic intermediate that is formed during the catabolism of Quercetin (HY-18085) by the human gut bacteria E. ramulus.
    Alphitonin
  • HY-N8353
    Stachybotramide 149598-71-0 98%
    Stachybotramide is a natural fungal metabolite with the property of modulating the activity of cholesteryl ester transfer protein (CETP). Stachybotramide stimulates the transfer of cholesteryl esters (CE) from high-density lipoprotein (HDL) to very-low-density lipoprotein (VLDL) and low-density lipoprotein (LDL), increasing the transfer efficiency by 1.3- to 1.5-fold. Stachybotramide slightly reduced the transfer of cholesteryl esters from LDL and VLDL to HDL at 0.5 mM. The effect of Stachybotramide on the transfer of triglycerides (TG) from HDL was not significant. By these results, Stachybotramide was shown to preferentially stimulate the CETP-mediated transfer of cholesteryl esters from HDL to VLDL and LDL.
    Stachybotramide
  • HY-N8362
    1-Isomangostin 19275-44-6 98%
    1-Isomangostin is an inhibitor of pancreatic lipase. 1-Isomangostin inhibits porcine pancreatic lipase with an IC50 of 34.5 μM. 1-Isomangostin has anti-obesity activity.
    1-Isomangostin
  • HY-N8466
    (-)-Lyoniresinol 9'-O-glucoside 143236-02-6 98%
    (-)-Lyoniresinol 9'-O-glucoside is an inhibitor of ROS. (-)-Lyoniresinol 9'-O-glucoside reduces lipid accumulation and lipid metabolic disorders in FFAs-exposed HepG2 cells. (-)-Lyoniresinol 9'-O-glucoside inhibits high glucose-induced reactive oxygen species production.
    (-)-Lyoniresinol 9'-O-glucoside
  • HY-N8660
    Cimicifugic acid B 205114-66-5 98%
    Cimicifugic acid B is an antioxidant with an IC50 of 21 µM in the DPPH assay.
    Cimicifugic acid B
  • HY-N9010
    Chartarlactam A 1528745-88-1 98%
    Chartarlactam A is a novel compound with anti-hyperlipidemic activity. Chartarlactam A exhibits inhibitory potential in HepG2 cells.
    Chartarlactam A
  • HY-N9516
    Taurodehydrocholic acid 517-37-3 98%
    Taurodehydrocholic acid is a biliary cholesterol secretion activator. Taurodehydrocholic acid significantly increases the expression of Abcg5 and decreases the expression of abc8. Taurodehydrocholic acid can be used in the study of cholesterol metabolism.
    Taurodehydrocholic acid
Cat. No. Product Name / Synonyms Application Reactivity